When you step into a role, what do you want the purpose of the company you work for to be? How does that align with the individual purpose that motivates your ambition? As the only independent Medical Research institute in Australia focused on childhood cancer, our purpose is to translate and discover (through world class research), new treatments that will cure cancer and reduce the side effects in children and adolescents. We save & change lives. At The Children’s Cancer Institute we believe that a life should be long. Cancer cuts life short for hundreds of children every year, before they’ve even had a chance to make their mark. We aim to not only improve their quality of life, but eradicate the cause of their pain. Choose to be part of a team that will nurture your talent and grow your career, so you too can contribute to this purpose. Together, we can and we will cure all children of cancer. It’s not if. It’s when. In this position, you will play an important role into generating the best laboratory evidence to ultimately drive clinical translation of results for one of the most difficult-to-treat types of childhood cancer, called sarcoma. The position will include work on in vivo sarcoma patient-derived xenograft models, including tumour implantation, in vivo therapy experiments, post-treatment tumour analysis (eg immunohistochemistry, western blot), and survival/growth analysis. We have a range of promising drugs lined up for in vivo testing, and a very real possibility that if these drugs continue to perform well in our experiments, accelerate clinical translation. It will also involve assisting in the molecular and functional studies of sarcoma cell lines and sarcoma samples, including examining the consequences of mutations/fusions, developing functional genomic screens, test drug responses, examine (phospho)protein signal transduction pathways, and identifying potential drug targeting strategies. As our Research Assistant your purpose will be to: Set-up and work with sarcoma patient-derived xenograft (PDX) models. This will involve the subcutaneous engraftment of PDXs, monitoring, and treating via oral gavage or IP. Assist with the development and maintenance of primary sarcoma cell lines Assist with drug screens and molecular work in the sarcoma cell line models Assist with general laboratory management including contributing to ordering supplies, maintaining laboratory inventory Achieve an outstanding level of competence in all aspects of experimental work Contribute to quality publications Be involved in professional activities Collate, organise and present experimental results Be compliant with OH&S requirements for handling of human samples and according to Institute policies Abide by privacy legislation, ethics guidelines and the legal requirements for research involving human material To succeed you will have… Experience with in vivo mouse models/techniques is highly desirable but not essential, as training can be provided. Handling/restraint, oral…
Click here to view more detail / apply for Research Assistant
Click here to view more detail / apply for Research Assistant
